|
KMID : 1098420050130050227
|
|
Korean Journal of Medicinal Crop Science
2005 Volume.13 No. 5 p.227 ~ p.232
|
|
|
Antioxidant Effect of Flavonoids Isolated from the Root of Clematis trichotoma Nakai
|
|
Hung Tran-Manh
Thuong Phuong Thien
Bae Ki-Hwan
|
|
|
Abstract
|
|
|
|
The antioxidant effect of methanol extract (ME) and water extract (WE) from Clematis trichotoma was evaluated as primary study to scavenge stable 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), inhibited iron-induce lipid peroxidation in linoleic acid emulsion, peroxidation of liposome induced by Fe^{3+}/H_2O_2/ascorbie acid, and on Fe^{2+}/H_2O_2 induced the mitochondrial lipid peroxidation. In secondary study, five flavonoids as luteolin (1), quercetin (2), apigenin (3), hirsutrin (4), kaempferol-3-O-glucoside were isolated (5). Among them, compounds 1 and 2 showed good activities in all the model systems. Compound 3 exhibited moderate antioxidant activities in both radical scavenging and these lipid peroxidation systems tested. Compound 4 showed significant inhibitions in liposome peroxidation and compound 5 displayed weak inhibition in all four tested systems. All the results presented herein indicate that products of C. trichotoma maybe useful in inhibiting membrane lipid peroxidation and preventing free radical-linked diseases.
|
|
|
KEYWORD
|
|
|
Clematis trichotoma, flavonoids, antioxidant, lipid peroxidation, free radical
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|